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2016 Jun 28;9:104-113

They produce modest body composition shifts, typically reduced visceral fat and improved muscle tone over months, not dramatic weight loss

(2002) Neoadjuvant therapy before radical prostatectomy for clinical T3/T4 carcinoma of the prostate: 5-year follow up, Phase II Southwest Oncology Group Study 9109

May influence gene expression , promoting cellular repair, reducing oxidative stress, and restoring extracellular matrix integrity

Progress measurement should encompass multiple parameters including subjective improvements in energy and sleep quality, objective changes in body composition, laboratory marker improvements, and overall quality of life enhancements