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According to the American Cancer Society, pipe smoking is associated with a striking increase in laryngeal cancer mortality, with a relative risk (RR) of approximately 13.1

Marijuana affects everyone differently

Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures

Food and Drug Administration's Center for Tobacco Products

Its not just tobacco & nicotine intake that makes quitting hard, but also the "hand to mouth motion"

Also in the 1950s, Gunsmoke on both radio and TV was similarly sponsored primarily by Chesterfields and L&Ms