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It is worth noting that while this manuscript was in preparation, Kularatne and colleagues described how four ester derivatives of NAC, including NACET, were able to protect RPE cells against oxidative damage induced by treatment with hydroquinone (HQ), a component of cigarette smoke [21]

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Furthermore, in vitro analysis demonstrated that GPX4-overexpressing cells were resistant to reactive oxygen species-induced cell death ( P = 0.0360)