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Hydroxyproline is a major collagen amino acid that is normally disposed of through the kidneys as oxalate, a kidney stone trigger

Since insulin resistance and diabetes mellitus are risk factors for PD (50) and are associated with disease progression and severity, a KDs significantly reduced carbohydrate consumption may result in improved disease outcomes

This depletion of GSH results in a worsening effect in many disease models

Elucidating how Nrf2 preferentially upregulates target genes to avert various forms of oxidative cell death could facilitate the design of new treatments and preventative strategies for iron-associated illnesses

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