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Studies have found that under hypoxic conditions, HIF1 induced STAT3 via JAK or adenylate receptor 2B pathway, which upregulates the IL-6 and NANOG to maintain the CSC phenotype and also enhances the production of VEGF, required for the self-renewal ability of CSCs (79)

Follow Up and Outcomes All patients in our database had been or were being followed up for one year

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Moreover, Croziers group demonstrated a nano-optical tweezer based on all-silicon nanoantennas without deleterious thermal effect 59