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Hence, the SAM/SAH ratio dictates methyltransferase activity in vivo

74 ZhangX.ZhuJ.XingR.TieY.FuH.ZhengX.et al

Succinate and fumarate Inactivating mutations in TCA cycle enzymes fumarate hydratase (FH) and succinate dehydrogenase (SDH) are driver mutations in a subset of human cancers and they mediate epigenetic reprogramming

Acknowledgements This work was supported by the Intramural Research Program of the NIH/National Institute of Environmental Health Sciences 1Z01ES090079

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10.1046/j.1365-313X.1997.12040875.x Plant J