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In addition, the depletion of NMD factors, including Upf1, delays spontaneous differentiation to embryoid body (EB) formation, suggesting that NMD may be involved in the early stage of differentiation 15

Furthermore, during tumor proliferation, the UPS may influence various oncogenic signaling cascades, concurrently dysregulating multiple pathways and thereby complicating the development of targeted therapeutic strategies

Carbon monoxide (CO) modulates hydrogen peroxide (H(2)O(2))-mediated cellular dysfunction by targeting mitochondria in rabbit lens epithelial cells

If homocysteine concentrations are raised, dietary modification, optimisation of folate and B vitamin intake, and where appropriate, targeted supplementation can often reduce levels

Anthracyclines/trastuzumab: New aspects of cardiotoxicity and molecular mechanisms

The microbiome and the immune system are critically intertwined