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Patients on chronic L-DOPA therapy, both MPTP patients and non-MPTP, see significant increases in Hcy levels in the SNc (Bhattacharjee et al., 2016)

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72 Acute fasting and pyruvate deprivation in vivo and in vitro increase glycolytic gene and protein expression in the ovaries, decrease AMPK activity, and enhance mTOR activation, which in turn leads to elevated phosphorylation of downstream proteins like Akt and FOXO3a, promoting primordial follicle activation

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