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Disclosures: Keiko Iwaisako: Nothing to Disclose, Hiroaki Fuji: Nothing to Disclose, Momoko Fujita: Nothing to Disclose, Reina Sawabu: Nothing to Disclose, Shoko Tsukamoto: Nothing to Disclose, Masaki Yamamoto: Nothing to Disclose, Ryo Tofukuji: Nothing to Disclose, Masataka Asagiri: Nothing to Disclose, Daichi Nakamura: Nothing to Disclose, Keisuke Okura: Nothing to Disclose, Takahiro Nishio: Nothing to Disclose 1945 NRF2-MEDIATED IMMUNE COLD TUMOR MICROENVIRONMENT CONTRIBUTES TO RESISTANCE TO ATEZOLIZUMAB AND BEVACIZUMAB IN ADVANCED HEPATOCELLULAR CARCINOMA Shuhei Yamamoto 1 Takahiro Kodama 1 Kazuki Maesaka 1 Akifumi Kuwano 2 kenta Motomura 2 Kumiko Shirai 1 Akira Doi 1 Kazuhiro Murai 1 Yuki Tahata 1 Yoshinobu Saito 3 Hayato Hikita 3 Tomohide Tatsumi 1 Tetsuo Takehara 1 , 1 Osaka University, 2 Iizuka Hospital, 3 Osaka University Graduate School of Medicine Background: Atezolizumab/ bevacizumab (Atezo/Bev) combination immunotherapy is the first-line treatment for advanced hepatocellular carcinoma (HCC), but around 20% of patients do not respond initially

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