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Description

Generally speaking, the H-site is built from elements from both the N- and C-terminal domains

Alli (previously Orlistat GSK) European Medicines Agency (EMA)

Nature 469 , 343349 (2011)

In another embodiment, the siRNA compound is exactly complementary to a target RNA, e.g., the target RNA and the siRNA compound anneal, for example to form a hybrid made exclusively of Watson-Crick base pairs in the region of exact complementarity