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Toxic peptides are capable of inducing mucosal damage when administered in vivo on the intestine, whereas peptide is considered to be immunogenic if it is able to specifically stimulate HLA-DQ-restricted T cell lines isolated from peripheral blood of CD patients [82]

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This explains why the plasma contains the administered forms of cyanocobalamin and aquacobalamin, and their conversion into coenzyme forms, methylcobalamin and 5,5-adenosylcobalamins, has not been demonstrated in this physiological environment

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