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Lukianova-Hleb EY, Belyanin A, Kashinath S, Wu X, Lapotko DO

LeiX-LYangQ-LWeiY-ZQiuXZengH-YYanA-Met al

doi: 10.1146/annurev-physiol-021115-105202 72 MastrogiannakiMMatakPKeithBSimonMCVaulontSPeyssonnauxC

Previous studies at a dosage of up to 10 mg/kg caffeine showed no anxiolytic or anxiogenic effects in an open-field test and an elevated plus-maze test (Bhattacharya et al

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The study also showed that GHK-Cu was able to decrease the production of IL-6 and TNF-1 while increasing the activity of superoxide dismutase by blocking the activation of NFBs p65 and p38 MAPK