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We tested 2 prominent CFTR correctors, C3 (VRT-325) and C4(Corr 4a)- (45), and observed that endogenous cystinosin(7) did indeed increase stability of the ER form as well as a portion of the lysosome form (Figure 7C)

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The absence of a monovalent cation in proximity to the active site suggests that the catalytic activity of archaeal SAHHs/SIHHs is independent of monovalent cations

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Studies have explored its role in: Angiogenesis: The formation of new blood vessels, a critical process for healing damaged tissue