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421,422,423,424,425 Future directions Future translational arterial stiffness research should (i) enhance clinical assessment (e.g., multimodal imaging, wearable-based PWV analysis in large clinical trials and population studies), (ii) identify specific phenotypes and endotypes, (iii) decipher the underlying mechanisms of the use of state-of-the-art technologies (e.g., specific microfluid cell culture systems, machine learning approaches) and new risk factors (e.g., chronic psychosocial stress, air pollution), and (iv) develop tailored prevention and therapeutic approaches (e.g., new pharmacological agents targeting low-grade systemic inflammation, AI-based personalized intervention)

Laura Jacobsen, M.D

Efficacy and safety of tranexamic acid 5% cream vs hydroquinone 4% cream in treating melasma: A split-face comparative clinical, histopathological, and antera 3D camera study

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Similarly, rosemarinic acid has been incorporated as a dietary supplement to battle fatigue in cancer patients and it was under phase 3 trial (ClinicalTrials.gov ID NCT04546607)