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Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-nave patients with type 2 diabetes (SUSTAIN 4): a randomized, open-label, parallel-group, multicentre, multinational, phase 3a trial

Increased CB1 expression in activated stellate cell, along with heteromerization with AT1R may enhance AT1R-mediated profibrotic activity, leading to excessive production of ECM components, including collagens