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Western blotting showed increased levels of cleaved PARP-1 and cleaved caspase-3 in SA-treated mice consistent with SA-induced apoptosis

doi: 10.1159/000504344 11 BakerJBoothSDungwaJHighamASinghDLeaS

Birsen et al (165) demonstrated that APR-246-induced AML cell death was inhibited by iron chelators, lipophilic antioxidants and lipid peroxidation inhibitors, suggesting that APR-246 induced ferroptosis in AML cells