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Dose extrapolation is poorly handled

Post of the Department of Psychiatry at George Washington School of Medicine, in a written commentary in PNAS

In this study, NAC-based therapy had beneficial effects in repairing voiding function and regenerating the denuded urothelium, as well as in relieving tissue fibrosis and inflammation in the LPS-induced cystitis rat model

Freidman N, Chen I, Wu Q, Briot C, Holst J, Font J, Vandenberg R, Ryan R (2020) Amino acid transporters and exchangers from the SLC1A family: structure, mechanism and roles in physiology and cancer

Every cell in the treatment area gets the same instruction: turn over faster, build collagen now

Although the efficacy of general measures in managing HS has not been formally evaluated, the associated benefits are illustrated in case studies