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Szabo S, Deng X, Khomenko T, Chen L, et al

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such direction dependence is known as hysteresis

While there's no official upper limit, doses up to 2,000 mcg can be safely used to treat B12 deficiency under medical supervision

Additionally, if the 2.4-mg maintenance dose is not tolerated, the dose may be temporarily reduced to 1.7 mg for up to 4 weeks

It's the professional standard for a reason