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doi: 10.1152/ajpendo.00365.2018 156 MatiasIGonthierM-POrlandoPMartiadisVDe PetrocellisLCervinoCet al

PMID: 33150472

As noted above, mTOR signaling has emerged as a key control point for B cell functions 35

Such results are consistent with growing evidence that alternate ligands for GPCRs exhibit biased agonism

However, diabetes in these models is often associated with elevated hypercholesterolemia compared to nondiabetic controls, making it difficult to elucidate whether the observed effects on atherogenesis are due to hyperglycemia specifically