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Unfortunately, treatment with the multi-strain probiotic VSL#3 in non-obese males (Boutagy et al., 2015) and the probiotic strain Lactobacillus casei Shirota in patients with metabolic syndrome did not reduce the increased fasting plasma TMAO levels after a HFD (Tripolt et al., 2015)

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These include the following: therapeutic benefits resulting from non-antioxidant mechanisms, insufficient dosage to elicit an antioxidant effect, poor oral bioavailability, a narrow therapeutic index, or toxicity that precludes clinical use

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Description 5-Amino-1MQ is positioned in research contexts as an NNMT (nicotinamide N-methyltransferase) pathway small molecule, not an NMN (nicotinamide mononucleotide) profile, with interpretation generally anchored to broader NNMT inhibition literature