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VARSITY TRIAL SECONDARY END POINTS Overall population DIFFERENCES YOU CAN SEE ENTYVIO demonstrated superiority to Humira in endoscopic improvement at Week 52 2 * ENTYVIO IV Humira (adalimumab) CI=confidence interval

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The overall RA disease activity score in this study measured by DAS28 was at the lower range and may reflect an effective treat-to-target treatment regime with good access to synthetic and biologic disease modifying anti-rheumatic drugs (respectively s-DMARDs and b-DMARDs)

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Cardiometabolic Disorders Cardiometabolic disorders are a collection of interrelated conditions, mainly dyslipidemia, insulin resistance, impaired glucose tolerance, hypertension, and central adiposity (Zhang et al., 2011