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Not all have strong clinical trials behind them, but many are supported by microbial biology, historical use, and case reports

This approach maximizes stability compared to long-term mixture storage

65,66,67 Although the risk factors for PDPN are poorly understood, female sex, longer diabetes duration, increased neuropathy severity, renal dysfunction, higher HbA1c levels, and higher BMI have been suggested as contributing factors

The enteric nervous system is part of the autonomic nervous system, which also includes the sympathetic (flight, fright or freeze) and the parasympathetic (rest and digest) nervous systems

The organ that is most affected by B12 deficiency is the nervous system and brain

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