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At the same time, 4-HNE is highly cytotoxic causing protein and DNA damage (199, 211213), affecting autophagy (214, 215), and inducing cell apoptosis (216)

8) Liver Function Normal NAD+ levels in the body are essential for the optimal functioning of the liver

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27,395 In these mice, liver NADPH contents drop significantly while MDA and mRNA levels of Ptgs2 increase