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Similar content being viewed by others Introduction CD38 is a 45-kDa type-II transmembrane glycoprotein that serves as both an important receptor and ectoenzyme [1, 2]

(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field

It was recently found, for instance, that NNMT was preferentially expressed by mesenchymal glioblastoma stem cells (GSCs)

In addition to improving your metabolism, it can also help in losing weight

Understanding the consequences of NNMT inhibition has implications for research into metabolic regulation and potential therapeutic applications