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Table 2 summarizes the mechanical stimuli applied to synovial fibroblasts, their intensity and mode of application, their effects, and any analogies to TGF- signaling

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Lipid peroxidation, degradation of proteins, and DNA strand damage are all carried out by reactive oxygen species (ROS), which seriously impair cellular metabolism

Cathepsin B, a cysteine protease presents in the late endosome and lysosome compartments in mammals, is also overexpressed in many cancer cells

wherein to the circulating levels of glutathione are increased to achieve clinically beneficial effects

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