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The collagen synthesis mechanisms involve MAPK/ERK pathway activation, which upregulates collagen gene expression at the genetic level

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As of 2022, it is included in WADAs prohibited substances list

Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging

FIGURE 2 3.3 Hypoxic-glucose deprivation conditions can induce senescence in endothelial cells Unlike the previously mentioned natural aging models and progeria models, there is another common but often overlooked endothelial cell aging model: hypoxia-induced endothelial cell senescence