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The peptide also influences the hypothalamic-pituitary axis, affecting stress hormone levels and circadian rhythm regulation

The main function of granulosa cells, relevant to oocyte development and ovarian functions, is steroidogenesis, for which different signaling pathways, including Jak/STAT, PI3K/Akt, and pro-MAPK/ERK1/2, regulate this fundamental process, all of which have a shared modulator named IGF

The researchers found that organic acids, specifically acetic and gluconic acids, were the most effective in this process

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