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Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-Mediated cell death

However, cancer cells can escape cellular ferroptosis by activating or remodeling various signaling pathways, including oxidative stress pathways, thereby limiting the efficacy of ferroptosis-activating targeted therapy

Palmitoylated Synaptotagmin-11(Syt11) promotes aberrant S aggregation by decreasing S tetramerization and increasing its aggregation-prone monomer, suggesting that the two functionally related vesicular transport proteins may synergistically regulate S homeostasis through palmitoylation in mouse primary neurons and in cells of origin from familial Parkinsons disease patients (177)

Pfaller, M

2025;25(1):156.[DOI] 175

This is a limiting factor especially for radioligands that are not yet approved for clinical use, because most hospitals with PET scanners would not have access to experimental radioligands