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Overexpression of cyclooxygenase-2 (COX2) is also responsible for dopaminergic neuronal loss via oxidative stress-mediated inflammation

Jason Brause, MAFelicitas A

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Hepatology 46 , 13921403 (2007)

In agreement with earlier research, our findings demonstrated that abemaciclib triggers the endoplasmic reticulum (ER) stress response, modifies the mitochondrial membrane potential, and consequently causes loss of membrane integrity, cytochrome c release, ROS generation, cellular endogenous antioxidant depletion, caspase activation, pro-apoptogenic proteins BAX and P53 upregulation, and anti-apoptogenic protein Bcl-2 downregulation

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