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One of the most intriguing compounds in this arena is the synthetic peptide FOXO4-DRI

doi: 10.3389/fphar.2021.632295 Received 07 December 2020 Accepted 13 April 2021 Published 10 June 2021 Volume 12 - 2021 Edited by Chiara Bianca Maria Platania, University of Catania, Italy Reviewed by Doreen Schmidl, Medical University of Vienna, Austria Francesca Lazzara, University of Catania, Italy Updates Copyright 2021 Zlatar, Kokot, Vuletic, Masnec, Kralj, Perisa, Barisic, Radic, Milanovic, Drmic, Seiwerth and Sikiric

Key Mechanistic Differences# Dosing Comparison# CagriSema Dosing# CagriSema is administered as a once-weekly subcutaneous injection at a target fixed dose of 2.4 mg cagrilintide + 2.4 mg semaglutide

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Local inhibitory network GIPR-expressing neurons in the dorsal vagal complex (AP/NTS) are predominantly GABAergic with Gad1/Gad2 co-expression