mrp1 glutathione sirt1 deficiency promotes age-related heart failure through enhancing ferroptosis via GATA4-HADHA-GPX4 axis Oncology Letters

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Sex-based differences in insulin resistance

Metal binding peptides can be prepared by standard solid-phase peptide synthesis (SPPS) protocols, and optionally incorporate synthetic or non-naturally occurring amino acids and peptide backbone modifications

The PI3K/AKT axis drives fibrotic responses via AKT/mTOR and PAK2/c-Abl signaling [43, 44], while the MEK/ERK pathway contributes to pulmonary fibrosis, particularly under Bmi-1 deficiency [45]

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doi: 10.3389/fendo.2026.1766838 Received 13 December 2025 Revised 20 January 2026 Accepted 26 January 2026 Published 10 February 2026 Volume 17 - 2026 Edited by Duan Xing, Southeast University, China Reviewed by Sandeep Das, Louisiana State University Health Shreveport, United States Fatimah Usman, Sriwijaya University, Indonesia Updates Copyright 2026 Natarajan, E