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[16] [17] [18] It was also established that GHK-Cu stimulates both the synthesis of metalloproteinases, the enzymes which break down dermal proteins, and their inhibitors (anti-proteases)

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Key aspects of non-transdermal technology include: No drugs or chemicals are delivered through the skin

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Latterly, further study of these receptors has been enabled by the use of subtype-selective drugs and transgenic mice, with one or more receptor subtypes genetically deleted

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