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doi: 10.3389/fmicb.2017.02015 Received 24 May 2017 Accepted 29 September 2017 Published 17 October 2017 Volume 8 - 2017 Edited by Michael Sauer, University of Natural Resources and Life Sciences, Vienna, Austria Reviewed by Armen Trchounian, Yerevan State University, Armenia

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Tumor-associated macrophages (TAMs), especially CD163+ TAMs, are an essential component of the tumor microenvironment and maintain a critical role in orchestrating tumor progression, metastasis and resistance to therapies