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Funding Statement This work was supported by PON-MIUR 03PE000_78_1, PON-MIUR 03PE000_78_2, and PRIR Calabria Asse 1/Azione 1.5.1/FESR (Progetto AgrInfra Calabria), PRIN 2022 PNRR COD: P2022FAS5R and SAP01-2023-000077Bando A Cascata Rome Technopole Spoke 1 e Spoke 6-PRODIGI

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RCT 164 low-risk (no hospitalizations) patients in Tunisia, showing improved recovery with zinc, melatonin, and vitamins A-E

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PMID: 1869275

Decreased availability of glutamate limits anaplerosis of the TCA cycle, resulting in low mitochondrial respiration, and nitrogen source, resulting in the high dependency on exogenous non-essential amino acids