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The nausea is both dose-dependent and time-dependent, meaning higher doses produce more nausea, and symptoms are most prominent during treatment initiation before the body adapts to the medications effects

10.1016/j.lfs.2015.09.016 51 KimM.-J.SinamI

PATHOPHYSIOLOGY The syndrome is a complex, multifactorial disorder of the brain-gut axis of as yet unclear pathogenesis, often associated with other episodic conditions like migraine headaches and abdominal migraine [9]