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Tirzepatide produced greater A1c reductions than semaglutide in the SURPASS-2 head-to-head trial, making it the stronger option for glycemic control

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However, lacking trials conducted with tirzepatide, an updated comparison among available anti-obesity medications (AOM) is warranted

However, in agreement with our detected concentrations by HF-LPME, previous measured whole-body concentrations of weakly acidic sulfonamides and weakly basic diphenhydramine in fish significantly increased with increases in the neutral molecule forms 31,32 , suggesting that the acceptor concentration in HF-LPME can be used as a surrogate for the internal concentration in D