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300 As mentioned earlier, H 2 O 2 expression results in dimerization and subsequent initiation of ASK1, which initiates p38 MAPK and JNK, stabilizing p53

doi:10.1007/s13300-019-0619-1 33

Statements Author contributions AEP conceived the idea, surveyed the literature and wrote the manuscript

However, the high total-body content of glutathione (probably in the range of 40 to 80 gm in a 70 kg adult) and the relatively short half-life of this reactive and metabolically important compound (4 to 10 hours in most tissues) render glutathione replacement extremely difficult to achieve in practice

Because vitamin C helps keep the glutathione pool in its active form, your blood's overall antioxidant protection capacity may improve, rather than just the level of one nutrient in isolation

Clinical description All patients with 5-oxoprolinase deficiency have been identified because of 5-oxoprolinuria (4 to 10 g/day