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While the exact effects of superfluous NO or its derivatives on synaptic function in PD have not been fully elucidated, there is evidence that excess NO alters axo-dendritic function, specifically impairing neurite length through the S-nitrosylation of protein disulfide isomerase or microtubule associated protein 1b, and causing synaptic spine loss through the hyperactivity of Cyclic-dependent kinase 5 (CDK5) following CDK5 S-nitrosylation 53,54

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232,234 MSC therapy to promote healthy endometrial tissue has also been proposed as a future treatment for endometrial problems related to infertility, such as Asherman syndrome (intrauterine adhesions) and possibly even endometriosis

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