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305 In a randomized controlled trial of 24 patients with IBS-D, the bile acid sequestrant colesevelam (Welchol) significantly increased ascending colon emptying time by four hours compared with placebo

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Additionally, the combined effects of oxidative stress and excitotoxicity activate both caspase-dependent and caspase-independent apoptotic pathways, leading to cellular fragmentation and neurodegeneration

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