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Fufang-zhenzhu-tiaozhi formula (FTZ), a patented TCM preparation, has been demonstrated to promote -cell regeneration by protecting the islets from inflammatory cell invasion, maintaining the number of pancreatic -cells, and increasing the expression of key markers of new -cell formation, such as PDX-1, MAFA, and NGN3 ( Puerarin has demonstrated a significant improvement in blood glucose homeostasis in HFD-induced diabetic mice

38 Iron overload Although iron is a helpful component of the human body and the major micronutrient in the human diet, involved in crucial cellular functions and metabolic processes, excessive iron increases the production of ROS, leading to cell dysfunction or death, tissue damage, and organ disease

Furthermore, the GCL enzyme is composed of a catalytic and modifier subunit (GCLC and GCLM, respectively)