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Chicago, IL: University of Chicago Press

doi: 10.3389/fmed.2025.1535673 Received 27 November 2024 Accepted 25 March 2025 Published 04 April 2025 Volume 12 - 2025 Edited by Vasilios Kotsis, Aristotle University of Thessaloniki, Greece Reviewed by Panagiota Anyfanti, Aristotle University of Thessaloniki, Greece Raina D Ramnath, University of Bristol, United Kingdom Updates Copyright 2025 Wang, Zhang, Qu and Zhou

A comparison was performed between the predicted exposure using in silico methods (described in item 2.3) and the measured bioactivity responses (i.e., PoDs as determined using the state-space model approach)

Injection-site reactions are among the most commonly reported side effects: patients may experience pain, stinging, or mild burning at the IM injection site