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SCN2.2 exposure to glutamate resulted in activation of the anti-apoptotic ERK/MAPK pathway without affecting the pro-apoptotic p38/MAPK pathway, whereas in GT1-7 was noted an increase in p38/MAPK pathway and decrease in ERK/MAPK pathway (Karmarkar et al., 2011

Impact of an MT-RNR1 gene polymorphism on hepatocellular carcinoma progression and clinical characteristics

3 Ferroptosis Ferroptosis can be suppressed by lipid peroxidation inhibitors, which is thought to be triggered by lipid peroxidation that depends on iron (Jiang et al., 2021)

However, while preclinical investigations of cardiovascular diseases have yielded promising results, melatonin has not met anticipated efficacy benchmarks in translational studies involving patients with established cardiovascular conditions

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As a result, we cannot confidently determine whether such compounds effectively reduce ROS levels at relevant sites of oxidative stress