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Cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA for genome editing

Clinically, patients with hypothyroidism and advanced hepatic fibrosis exhibit elevated liver stiffness values on elastography, which are strongly associated with increased HCC risk (97)

J Ethnopharmacol 323:117718 Chen Q, Xu Z, Li X, Du D, Wu T, Zhou S, Yan W, Wu M, Jin Y, Zhang J (2021) Epigallocatechin gallate and theaflavins independently alleviate cyclophosphamide-induced ovarian damage by inhibiting the overactivation of primordial follicles and follicular atresia

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Previous studies have shown that inhibiting SIRT2 may enhance the stability of glucokinase (GCK) regulatory proteins, accelerate aldolase A degradation, and inhibit -cell insulin secretion via modulation of the Akt/glycogen synthase kinase-3 (GSK3)/-catenin pathway, collectively reducing glycolytic flux (42)