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TRIM37 promotes cell invasion and metastasis by regulating SIP1-mediated epithelial-mesenchymal transition in gastric cancer

Clinically, umbilical vein endothelial cells from neonates with BPD exhibit compromised mitochondrial respiration (reduced oxygen consumption) alongside elevated OS (increased superoxide/H 2 O 2 production), directly linking endothelial mitochondrial failure to adverse outcomes (Kandasamy et al., 2017)

Interestingly, some bacterial pathogens have evolved mechanisms to counteract mtDNA-mediated immune activation

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Intensified Th9 response is associated with the immunopathogenesis of active ulcerative colitis

Mannes et al., 2011)