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The two approaches answer different research questions

10.1021/acschemneuro.9b00351 [DOI] [PMC free article] [PubMed] [Google Scholar] Sdhof TC, 2012

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The Moore Laboratorys mission is to understand the molecular pathogenesis of Parkinsons disease in order to develop novel targeted therapies and neuroprotective strategies to treat or prevent this devastating disease

A florescent probe like 2,7-dichlorofluorescein diacetate (H 2 DCFDA) penetrates the spermatozoa and indicates H 2 O 2 concentrations, as H 2 O 2 de-esterifies in the presence of DCFH and forms fluorescent 2,7-dichlorofluorescein (DCF) (47)

Oxidative Stress and Neuroinflammation Probing the Pathophysiology of ME/CFS through Neuroimaging The discovery of ME/CFS-specific biomarkers that can advance our understanding of the illness and its pathogenic mechanisms, differentiate the disorder from overlapping or comorbid diagnoses, and identify potential treatment targets is currently a pressing and unmet research and public health need