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Given the shifting roles of the PPP during disease processes, timed pharmacological interventions could be particularly informative, but unfortunately many PPP enzymes continue to lack specific inhibitors, and existing inhibitors require further optimization to enable routine in vivo application

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C., Fisher, J

Data from animal coronavirus vaccine development suggested that systemic cell-mediated or humoral immune reactions induced by parenteral management may not be enough to inhibit the virus invasion in the respiratory system (183)

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Previous studies demonstrated zebrafish has two GSDME, GSDMEa and GSDMEb, sharing about 50% sequence similarity to human GSDME, but only GSDMEa could trigger TNF-induced pyroptosis 32