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Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: April 5, 2026 Smoking significantly worsens acid reflux and GERD by weakening the lower esophageal sphincter (LES), increasing stomach acid production, and impairing the esophaguss ability to clear acid

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According to the Cleveland Clinic, examples of metabolic disorders include: Gaucher disease, which is marked by the buildup of fatty acids in organs, according to the Mayo Clinic Hemochromatosis, which leads to harmful levels of iron in the blood, per the National Institute of Diabetes and Digestive and Kidney Diseases Wilson disease, in which copper accumulates in vital organs, according to the Mayo Clinic Maple syrup urine disease, which is when the body has trouble processing certain amino acids, according to the National Organization for Rare Disorders Mitochondrial diseases, in which the mitochondria has trouble converting sugar and oxygen into energy, according to the Centers for Disease Control and Prevention Tay-Sachs disease, which occurs when an enzyme that breaks down fatty acids is not present, according to the Mayo Clinic Your metabolism can also slow if youre in the hospital or have a prolonged illness that limits your physical activity and therefore reduces your muscle mass, Griebeler says