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Conversely, in glioblastoma, inhibition of HSP60 increases mitochondrial ROS generation, triggering AMPK activation and suppressing mTORC1-mediated phosphorylation of S6K and 4EBP1

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High expression of GPX3 and MYC was significantly enriched in interferon-/ responses and TNF-/NF-B signaling pathways, whereas low expression was enriched in metabolic pathways such as fatty acid metabolism, bile acid metabolism, and oxidative phosphorylation

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10.1186/cc9388 Perez-Barcena J, Regueiro V, Marse P, Raurich JM, Rodriguez A, Ibanez J, de Lorenzo Mateos AG, Bengoechea JA: Glutamine as a modulator of the immune system of critical care patients: effect on toll-like receptor expression