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Mater Today Proc 49:26482653

8 Under diabetic conditions (eg, hyperglycemia and dyslipidemia), neural structure is disrupted, accompanied by bioenergetic deficits, impaired insulin signaling, inflammation, oxidative stress, microvascular damage (Figure 1b)

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444 However, Hct may also rebound after bloodletting, and frequent use can lead to metabolic disorders, making it an impractical long-term treatment

Because the maturation cycle for eggs is roughly 90 days and the sperm production cycle is similar, most practitioners recommend consistent use for at least three months