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The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/akt signaling pathway through a transcription factor complex containing CREB

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Research applications include innate repair receptor pathway studies, cytoprotective signalling research, and EPO-derived peptide structure-activity investigation

Mice that received anti-PD-L1 mAbs alone relapsed after 3 weeks accompanied with a tumor-associated PD-1/ T-cell immunoglobulin domain and mucin domain 3 (TIM-3) double-positive depleted T-cell phenotype

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consider supportive nutrients such as L-glutamine or zinc carnosine if appropriate